5‐nitroacenaphthene: A newly recognized role for the nitro function in mutagenicity

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Abstract
The direct‐acting mutagenicity of 5‐nitroacenaphthene for Salmonella typhimurium is dependent upon the reduction of the nitro function as evidenced by the significant decrease in mutagenicity seen with nitroreductase‐deficient Salmonella strains. Addition of microsomal preparations results in a significant increase in mutagenicity and a by‐passing of the block in nitroreductase‐deficient and arylhy‐droxylamine esterifying‐deficient enzyme strains. The results are taken to indicate that the microsome‐induced mutagenicity is due primarily to oxidation of the acenaphthene moiety. The results are consistent with recent studies which indicate that the nitro function exercises a directing effect on ring oxidation.

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