Serum Progesterone in Normal Pregnancy. Studies in an Asian Population

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Abstract
Summary: Progesterone was measured in 232 normal pregnancy sera by a competitive protein binding assay. The mean serum progesterone concentration increased gradually from 15.1 ng./ml. at 6 weeks of gestation to 22.5 ng./ml. at 8 weeks, dipped slightly to 18.8 ng./ml. at the ninth week and then rose steeply during the second and third trimesters to reach 180.5 ng./ml. at term. There was a 5.5‐fold difference between the lowest and highest concentrations of serum progesterone for any period of gestation. In 5 patients investigated for diurnal changes there were small, random fluctuations in the serum concentration. The mean umbilical venous serum progesterone concentration in 10 babies was 4.5 times higher than the corresponding maternal venous concentration.

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