Comparison of taurine chloramine and taurine bromamine effects on rheumatoid arthritis synoviocytes
- 31 July 2006
- journal article
- clinical trial
- Published by Springer Nature in Amino Acids
- Vol. 32 (3) , 447-452
- https://doi.org/10.1007/s00726-006-0368-0
Abstract
Summary. Fibroblast-like synoviocytes (FLS) participate in rheumatoid arthritis (RA) chronic synovitis by producing pro-inflammatory cytokines (IL-6, IL-8), growth factors (VEGF) and other inflammatory mediators (PGE2, NO). We have previously reported that Tau-Cl, generated by neutrophils, inhibits in vitro some of these pathogenic RA FLS functions. Taurine bromamine (Tau-Br) originates from eosinophils and neutrophils, and its immunoregulatory activities are poorly known. Therefore, we investigated the effects of Tau-Br on RA FLS functions and compared it to Tau-Cl anti-inflammatory action. When applied at noncytotoxic concentrations: (i) Tau-Br inhibited IL-6 and PGE2 production with potency similar to Tau-Cl (IC50 ≈ 250 µM), (ii) Tau-Br failed to affect VEGF and IL-8 synthesis, while Tau-Cl exerted inhibitory effect (IC50 ≈ 400 µM), (iii) none of these compounds affected NO generation and iNOS expression. Thus, Tau-Cl is more effective than Tau-Br in normalization of pro-inflammatory RA FLS functions.Keywords
This publication has 28 references indexed in Scilit:
- Taurine Chloramine Inhibits Production of Inflammatory Mediators and iNOS Gene Expression in Alveolar Macrophages; a Tale of Two Pathways: Part II, IFN-γ Signaling Through JAK/StatPublished by Springer Nature ,2003
- Taurine Chloramine Inhibits Production of Inflammatory Mediators and iNOS Gene Expression in Alveolar Macrophages; a Tale of Two Pathways: Part I, NF-κB SignalingPublished by Springer Nature ,2003
- Anti-inflammatory Activities of Taurine ChloraminePublished by Springer Nature ,2003
- Chemical Properties of N-Chlorotaurine Sodium, a Key Compound in the Human Defence SystemArchiv der Pharmazie, 2002
- Taurine chloramine modulates cytokine production by human peripheral blood mononuclear cells.Amino Acids, 2002
- Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsisProceedings of the National Academy of Sciences, 2001
- Taurine chloramine inhibition of cell proliferation and cytokine production by rheumatoid arthritis fibroblast-like synoviocytesArthritis & Rheumatism, 1999
- NITRIC OXIDE PRODUCTION IN CELLS DERIVED FROM THE HUMAN JOINTRheumatology, 1996
- SYNOVIAL FLUID POLYMORPHONUCLEAR LEUCOCYTES FROM PATIENTS WITH RHEUMATOID ARTHRITIS HAVE REDUCED MPO AND NADPH-OXIDASE ACTIVITYRheumatology, 1990
- Bromine derivatives of amino acids as intermediates in the peroxidase-catalyzed formation of singlet oxygenArchives of Biochemistry and Biophysics, 1989