Application of Combinatorial Procedures in the Search for Serine-Protease-Like Activity with Focus on the Acyl Transfer Step

Abstract
Recursive deconvolution of a 729‐membered peptide library has identified three active sequences, in which both Ser and His are present in one of the two tripeptidic chains generated on a steroidal scaffold (see structural formula), for the cleavage of an activated p‐nitrophenyl ester. This combinatorial approach aims at searching for serine‐protease‐like activity.

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