Inhibition of intercellular communication and enhancement of morphological transformation of Syrian hamster embryo cells by TPA. Use of TPA-sensitive and TPA-resistant cell lines

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Abstract
The possible role of blocked intercellular communication in the process of cell transformation has been studied with Syrian hamster embryo cell lines which are sensitive or resistant to TPA-induced enhancement of morphological transformation. Both the TPA-sensitive ( BPNi ) and the TPA-resistant ( 83–106 and 74–100 ) cell lines showed gap-junctional communication when measured by a dye-transfer method. However, TPA inhibited the communication only in TPA-sensitive cells, and not in TPA-resistant cells. These results are consistent with the idea that blocked intercellular communication is involved in a late stage of cell transformation and/or expression of the transformed phenotype.