Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography.
Open Access
- 1 August 1986
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 49 (8) , 853-860
- https://doi.org/10.1136/jnnp.49.8.853
Abstract
L-[18F] fluorodopa was administered in trace amounts intravenously to healthy control subjects and to patients with Parkinson's disease. Striatal uptake of radioactivity was measured using positron emission tomography. The capacity of the striatum to retain tracer was severely impaired in patients compared to controls. This may reflect a reduction of striatal dopamine storage in Parkinson's disease. Patients showing the "on/off" phenomenon had an even greater decrease of striatal storage capacity.This publication has 20 references indexed in Scilit:
- Positron emission tomography of the brain: new possibilities for the investigation of human cerebral pathophysiologyProgress in Neurobiology, 1984
- Dopamine visualized in the basal ganglia of living manNature, 1983
- Effects of 3‐OM‐dopa on monoarnine metabolism in rat brainNeurology, 1983
- 3‐O‐ methyldopa blocks dopa metabolism in rat corpus striatumAnnals of Neurology, 1982
- A new autoradiographic approach for imaging forebrain dopamine distributionAnnals of Neurology, 1982
- THE SITE OF DOPAMINE FORMATION IN RAT STRIATUM AFTER L-DOPA ADMINISTRATION1981
- Blood-brain barrier transport and cerebral utilization of dopa in living monkeysAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1980
- Evaluation of Parkinson's disease.1980
- ECAT - NEW COMPUTERIZED TOMOGRAPHIC IMAGING-SYSTEM FOR POSITRON-EMITTING RADIOPHARMACEUTICALS1978
- Intracerebral dopamine metabolism studied by a novel radioisotope techniqueJournal of Pharmacy and Pharmacology, 1976