Effect of Somatostatin on Bethanechol-Stimulated Gastric Pepsin Secretion in Gastric Fistula Dogs

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Abstract
The effect of somatostain on pepsin secretion was determined in 6 dogs with gastric fistulas during stimulation with bethanechol. Somatostatin inhibited dose-dependently the stimulated pepsin secretion, with a dose of 0.3 .mu.g/kg per h being 35% inhibitory during stimulation with bethanechol, 80 .mu.g/kg per h. Continuous infusion of somatostatin for 3 h did not cause any signs of tachyphylaxis. Withdrawal of somatostatin produced a return to the control level. The dose-response kinetics with 5 doses of bethanechol with and without somatostatin showed inhibition of a noncompetitive type. The effects of somatostatin were not altered by using adrenergic, dopaminergic or serotonergic blocking drugs.