A lethal mutation (cab) affecting heart function in the mouse
- 1 February 1979
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 33 (1) , 57-59
- https://doi.org/10.1017/s0016672300018164
Abstract
SUMMARY: A new autosomal recessive gene (cab, ‘cardiac abnormality’), which affects heart differentiation appeared spontaneously in our mouse colony. The affected homozygotes die approximately half a day prior to birth or at term, with the myocardium exhibiting vacuolation and large areas of mesenchyme-like cells. A significant finding in mutant foetuses is the lack of histochemically detectable glycogen.This publication has 4 references indexed in Scilit:
- Infantile cardiomyopathy with histiocytoid change in cardiac muscle cells. Report of six patients.Circulation, 1976
- Hereditary cardiomyopathy: A new disease modelAmerican Heart Journal, 1969
- Developmental genetics of a lethal mutation, muscular dysgenesis (mdg), in the mouseDevelopmental Biology, 1965
- Lethal Genes and Analysis of DifferentiationScience, 1963