Hemolytic Streptococcal Sore Throat: Antibody Response Following Treatment With Penicillin, Sulfadiazine, and Salicylates

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Abstract
Sera were obtained on about the 3d and 21st days from 351 cases of acute Group A hemolytic streptococcal sore throat. The antistreptolysin (ASL) titers were detd. by a modification of the usual technic. A 50% increase in this titer or a prolonged clot lysis for over 8 hrs. indicated significant antibody response. Antifibrinolysin (AFL) titers were also measured at similar intervals in 321 cases. 233 cases received only hot saline gargles, whereas chemo- or antibiotic therapy was begun in the others on the 2d or 3d sick day. The drugs included salicylates, sulfadiazine, penicillin alone and followed by sulfadiazine. No drug prevented formation of ASL or AFL. When penicillin treatment was prolonged the frequency of AFL response decreased. An ASL response also decreased in cases where bacteriol. relapse did not occur. It was possible that the exhibition of penicillin in amts. adequate to eliminate the streptococcus from the throat interfered with formation of these antibodies''.

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