Feline Oncornavirus-Associated Cell Membrane Antigen. VI. Cytotoxic Antibody in Cats Exposed to Feline Leukemia Virus2
- 1 June 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 56 (6) , 1197-1200
- https://doi.org/10.1093/jnci/56.6.1197
Abstract
Feline leukemia virus (FeLV)-infected specific-pathogen-free (SPF) cats, normal uninfected SPF cats, and healthy cats from leukemic households were tested for antibody reactive to the feline oncornavirus-associated cell membrane antigen (FOCMA)-containing target cell line FL-74 by microcytotoxicity and indirect membrane immunofluorescence. Of the infected SPF animals, 81% showed concordant reactivity for the two tests. In contrast, only 55% of the healthy cats known to be naturally exposed to FeLV for long periods showed such concordance. FOCMA antibody could not be detected in normal SPF cats by either indirect membrane immunofluorescence or microcytotoxicity. Most cats in the FeLV-infected SPF group developed antibody detectable by both procedures by the fifth week post inoculation. Antibody detectable by membrane immunofluorescence persisted in a high percentage (75–90%) of the animals throughout the observation period of 19 weeks; after 9 weeks, fewer cats had antibody that was also detectable by microcytotoxicity.Keywords
This publication has 1 reference indexed in Scilit:
- Studies on the Mechanism of Immunological Enhancement of Tumor Homografts. 1. Specificity of Immunological Enhancement2JNCI Journal of the National Cancer Institute, 1963