INHIBITION OF ANDROGEN-STERILIZATION IN THE FEMALE RAT BY ADMINISTRATION OF AN ANTIOESTROGEN

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Abstract
Treatment of female rats with testosterone propionate (TP) during the first few days of life induces an anovulatory syndrome which is accompanied by constant vaginal cornification in the adult animal (Barraclough, 1961; Gorski, 1971). Several recent studies have shown that the ring A reduced metabolites of testosterone do not produce sterilization in the female rat (Brown-Grant, Munck, Naftolin & Sherwood, 1971; McDonald & Doughty, 1972). The fact that these compounds cannot be converted to oestrogenic metabolites suggests that aromatization of testosterone could be involved in androgen sterilization. This preliminary report describes the effects of the antioestrogen MER 25 administered to neonatal testosterone-treated female rats. Female rats were treated on day 5 of life (day of birth = day 1) with either oil, 30 μg TP, 100 or 500 μg MER 25; 100 μg MER 25 plus 30 μg TP given at the same time, or 500 μg MER 25 plus 30

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