EFFECT OF IBOPAMINE ON DIURESIS AND ARTERIAL BLOOD-PRESSURE IN ANESTHETIZED RATS AND ITS INTERACTIONS WITH DOPAMINERGIC AND ALPHA-ADRENERGIC AND BETA-ADRENERGIC ANTAGONISTS

  • 1 January 1986
    • journal article
    • research article
    • Vol. 36-1  (2A) , 323-326
Abstract
The present paper reports a study of the effect of ibopamine (SB-7505), the 3,4-diisobutyryl ester of N-methyldopamine (epinine), on diuresis and blood pressure in anesthetized rats. The results obtained demonstrate that ibopamine, administered orally at doses of 12.5 to 200 mg/kg, caused a dose-dependent diuresis. The increase in blood pressure was moderate and of short duration. The diuretic effect of ibopamine was antagonized by d-sulpiride, haloperidol, bulbocapnine and phenoxybenzamine, but not by l-sulpiride and l-propranolol. The increase in blood pressure was antagonized by phenoxybenzamine only. The diuretic effect of ibopamine in rats reflects agonist activity at dopamine receptors and, in part, .alpha.-adrenoceptors and is independent of .beta.-adrenoceptors.

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