HYBRIDIZATION BETWEEN LYMPHOMA-T AND LYMPHOMA-B CELL-LINES
- 1 January 1980
- journal article
- research article
- Vol. 39 (1) , 57-60
Abstract
The AKR thymoma line BW 5147 was successfully hybridized with the Ig[immunoglobulin]M-bearing (BALB/c .times. NZB)F1 B [bone marrow-derived] lymphoma line WEHI 231. In the hybrids formed, T[thymus-derived]-cell characteristics were dominant, i.e., there was no expression of IgM but continued expression of Thy-1.1 in 8 of 8 lines. In 2 of 8 lines, the Thy-1.2 allele was also expressed. In its ability to hybridize, BW 5147 is not restricted to cells to similar ontogenetic origin (i.e., T cells) and fusion with the thymoma can lead to suppression of B cell gene expression and derepression of genes for T cell markers.This publication has 9 references indexed in Scilit:
- Production of an H–2-related suppressor factor by a hybrid T-cell lineNature, 1979
- T-cell lines producing antigen-specific suppressor factorNature, 1978
- Derivation of hybrids between a thymoma line and spleen cells activated in a mixed leukocyte reactionEuropean Journal of Immunology, 1977
- T lymphocyte tissue culture lines produced by cell hybridizationEuropean Journal of Immunology, 1977
- Hybrid cell lines with T-cell characteristicsNature, 1977
- Fusion of T and B cellsSomatic Cell and Molecular Genetics, 1977
- THE MECHANISM OF ANTIGENIC STIMULATION OF PRIMARY AND SECONDARY CLONAL PRECURSOR CELLSThe Journal of Experimental Medicine, 1972
- INCIDENCE OF IMMUNOGLOBULINS IN FLUIDS OF THE RABBIT GENITAL TRACTS AND THE DISTRIBUTION OF Ig-G-GLOBULIN IN THE TISSUES OF THE FEMALE TRACTReproduction, 1971
- Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed RecombinantsScience, 1964