Absolute configuration of epi-rhododendrin and (–)-rhododendrol [=(–)-betuligenol] and X-ray crystal and molecular structure of rhododendrin [= betuloside], a hepatoprotective constituent of Taxus baccata
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 11,p. 2687-2690
- https://doi.org/10.1039/p19910002687
Abstract
Rhododendrin (= betuloside) has been isolated from the leaves of Taxus baccata L. From its X-ray diffraction studies, the absolute configuration at the chiral centre in the aglucone portion has been found to be R. These results establish the stereochemical assignments to different samples of this glucoside isolated from different plants. Our sample of rhododendrin exhibited hepatoprotective activity against two hepatotoxins in rats.Keywords
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