Measurement of Connective Tissue Parameters in Serum for Diagnosis and Follow-Up of Liver Fibrosis

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Abstract
Hepatic fibrogenesis, i.e. activated synthesis and excessive intercellular deposition of connective tissue molecules (collagens, adhesive glycoproteins, proteoglycans) occurs in chronic alcoholic and viral liver injury and, less frequently, in some other conditions. The process may be monitored biochemically by the radioimmunoassay of some connective tissue molecules or their fragments and by the measurement of the activity of certain enzymes in serum. Currently, the radioimmunoassay of the aminoterminal propeptide of type III procollagen in serum reflects best the activity of liver fibrogenesis. The serum level of laminin, a high molecular weight basement membrane glycoprotein, was found to be correlated with an elevated portal venous pressure.