Hypoglycaemic agents
- 1 August 1964
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 16 (8) , 538-548
- https://doi.org/10.1111/j.2042-7158.1964.tb07510.x
Abstract
Various 3-substituted derivatives of 1-(p-vinylbenzenesulphonyl)urea, 1-[p-(2-chloroethyl)benzenesulphonyl]urea and 1-[p-(2-bromoethyl)benzenesulphonyl]urea are described. Several of the compounds possess noteworthy hypoglycaemic activity on oral administration in rabbits. In contrast, several related 5-substituted derivatives of 2-[p-(2-chloroethyl)benzenesulphonamido]-1,3,4-thiadiazoles and -1,3,4-oxadiazoles were virtually inactive.Keywords
This publication has 4 references indexed in Scilit:
- Potential Hypoglycemic Agents: 1,3,4-Oxadiazoles and Related CompoundsJournal of Medicinal Chemistry, 1962
- Relation Between Structure of Sulfonylurea Compounds and their Effect on Frog Muscle Metabolism.Experimental Biology and Medicine, 1958
- Preparation and Polymerization of p-Sulfonamidostyrene1Journal of the American Chemical Society, 1953
- Preparation and Polymerization of p-N,N-Di-methylsulfonamidostyrene1Journal of the American Chemical Society, 1947