Pregnancy Interception with a Combination of Prostaglandins: Studies in Monkeys
- 30 September 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4618) , 1407-1409
- https://doi.org/10.1126/science.6612350
Abstract
Treatment with combinations of synthetic prostaglandins, one with an ovarian site of action and one with a uterine site of action, terminated pregnancy in all rhesus monkeys given the injection on day 28 of fertile menstrual cycles. Single prostaglandins, even at higher doses, interrupted pregnancy in only one-third of the monkeys. The most effective treatment, 5-oxa-17-phenyl-18,19,20-trinor prostaglandin F1 alpha methyl ester plus 9-deoxo-16,16-dimethyl-9-methylene prostaglandin E2, promptly intercepted early pregnancy after a single administration and without side effects.This publication has 9 references indexed in Scilit:
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