Immunogenetic Aspects of Nasopharyngeal Carcinoma. IV. Increased Risk in Chinese of Nasopharyngeal Carcinoma Associated With a Chinese-Related HLA Profile (A2, Singapore 2)2

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Abstract
The results of this study of 110 Singapore Chinese with nasopharyngeal carcinoma (NPC) and 91 controls confirmed the association between the occurrence of HLA antigen Singapore 2 (Sin 2) and NPC in the Chinese population, and indicated that their increased risk for NPC was confined to the joint occurrence of Sin 2 and A2 antigens. These findings suggested that the genotype of importance in susceptibility to NPC is the A2-Sin 2 haplotype.