Effects of the Synthetic Analogue of Methionine Enkephalin FK 33-824 on Psychotic Symptoms

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Abstract
In an open pilot study, 9 schizophrenic patients were treated with the synthetic analogue of methionin-enkephalin FK 33–824 on two consecutive days in a dose of 0.5 mg on the first day, and 1.0 mg on the second day (infusion for 2 hours). 3 patients refused therapy during or after the first infusion; of the remaining 6 patients (2 hebephrenic, 4 paranoid type) 5 patients improved remarkably on the first and second day. The total BPRS-score and 4 of the 5 factors of the BPRS-scale were reduced significantly the day after treatment compared to pretreatment values. The improvement continued for 28–168 hours. In einer offenen Studie wurden 9 schizophrene Patienten an 2 aufeinanderfolgenden Tagen mit dem synthetisch modifizierten Methionin-Enkephalin FK 33–824 in der Dosierung 0.5 mg am 1. Tag und 1.0 mg am 2. Tag behandelt. 3 Patienten brachen die Untersuchung ab. Von den restlichen 6 Patienten (2 Hebephrene, 4 Paranoide) besserten sich 5 Patienten deutlich am 1. und 2. Tag der Behandlung. Der Gesamtwert der Brief-Psychiatric-Rating-Scale (BPRS) und 4 der 5 Unterfaktoren verminderten sich unter der Behandlung signifikant. Die Besserung hielt 28–168 Stunden an.

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