Repeated Naloxone Administration for Morphine Overdose in a 1-Month-Old Infant

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Abstract
Repeated injections of naloxone hydrochloride, a pure narcotic antagonist, were administered to a 3320 g 4 wk old boy for treatment of an accidental morphine overdose. The infant received frequent naloxone hydrochloride injections (0.2 mg per injection) during the first 12 h of therapy to reverse morphine-induced apnea, hypothermia, and flaccidity. A cumulative dose of 2.73 mg of naloxone hydrochloride (0.822 mg/kg) was administered over 27 h without apparent adverse effect or evidence of toxicity.

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