The human gene encoding insulin-like growth factor I is located on chromosome 12
- 1 February 1985
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 69 (2) , 157-160
- https://doi.org/10.1007/bf00293288
Abstract
A cDNA probe corresponding to mRNA encoding human somatomedin-C/insulin-like growth factor I (IGF-I) was used for the chromosomal assignment of the IGF-I gene. Southern-blot hybridization analysis of DNA from human-Chinese hamster somatic cell hybrids showed that the IGF-I gene is located on chromosome 12. Comparison of the chromosomal assignments of the IGF-I gene and two other members of the insulin gene family, with three c-ras oncogenes, reveals a remarkable association of the two gene families.Keywords
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