Murine V kappa gene expression does not follow the VH paradigm.
Open Access
- 1 May 1989
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 169 (5) , 1859-1864
- https://doi.org/10.1084/jem.169.5.1859
Abstract
V.kappa. gene family expression among LPS-reactive murine B lymphocytes, unlike that of VH gene families, is not proportional to genomic complexity, i.e., nonstoichiometric. Furthermore, no positional bias for the overexpression of J-proximal V.kappa. genes (V.kappa.21) is observed among neonatal B lymphocytes. Yet, the V.kappa. and V.kappa. 9 families located in the center of V.kappa. locus are preferentially used by neonatal B splenocytes. Thus, the mechanisms of V.kappa. gene rearrangement and expression appear to differ significantly from those controlling the VH locus.This publication has 25 references indexed in Scilit:
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