Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection
- 1 April 1996
- journal article
- clinical trial
- Published by Springer Nature in Nature Medicine
- Vol. 2 (4) , 405-411
- https://doi.org/10.1038/nm0496-405
Abstract
Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and transporter (TAP) genes (also part of the MHC) in homosexual seroconverters to human immunodeficiency virus type 1 (HIV–1). Comprehensive statistical analysis produced an HLA profile that predicted time from HIV–1 infection to the onset of AIDS. The profile was developed in a cohort of 139 men and evaluated in a second unrelated cohort of 102 men. In the evaluation cohort, the profile discriminated a sixfold difference between groups with the shortest and longest times to AIDS (P = 0.001). These findings support current theory about control of antigen processing by HLA genes and have implications for immunopathogenesis of HIV–1 and other infections.Keywords
This publication has 33 references indexed in Scilit:
- Major histocompatibility complex class II haplotypes and linkage disequilibrium values observed in the CEPH familiesHuman Immunology, 1994
- HIV-1 proteins in infected cells determine the presentation of viral peptides by HLA class I and class II molecules and the nature of the cellular and humoral antiviral immune responses—A reviewVirus Genes, 1994
- The Role of the Major Histocompatibility Complex in Human Immunodeficiency Virus Infection--Ever More Complex?The Journal of Infectious Diseases, 1994
- DISCRIMINATION OF HUMAN HLA‐DRB1 ALLELES BY PCR‐SSCP (SINGLE‐STRAND CONFORMATION POLYMORPHISM) METHODInternational Journal of Immunogenetics, 1994
- Typing of HLA-DQA1 and DQB1 using DNA single-strand conformation polymorphismHuman Immunology, 1992
- Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimerNature, 1992
- Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complexNature, 1992
- Common West African HLA antigens are associated with protection from severe malariaNature, 1991
- THE MULTICENTER AIDS COHORT STUDY: RATIONALE, ORGANIZATION, AND SELECTED CHARACTERISTICS OF THE PARTICIPANTSAmerican Journal of Epidemiology, 1987
- Statistical detection of HLA and disease associationTissue Antigens, 1985