Radioligand Binding and Inotropic Effects of Ryanodine in the Cardiomyopathic Syrian Hamster
- 1 April 1992
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 19 (4) , 610-617
- https://doi.org/10.1097/00005344-199204000-00019
Abstract
We compared the radioligand-binding and inotropic effects of ryanodine [known specific regulator of sarcoplasmic reticulum (SR) calcium release channel] on BIO 14.6 cardiomyopathic Syrian hamsters with those on age-matched F, B controls. Scatchard analyses of [3H]ryanodine binding to cardiac membranes prepared from 1–2-month-old BIO 14.6 and F1,B Syrian hamsters revealed the presence of a significant increase in binding capacity (Bmax = 942 ± 49 vs. 567 ± 33 fmol/mg protein) with no difference in affinity (KD = 3.9 ± 0.4 vs. 3.5 ± 0.5 nM, pKeywords
This publication has 0 references indexed in Scilit: