Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction
Open Access
- 15 January 1999
- journal article
- Published by The Company of Biologists in Development
- Vol. 126 (2) , 229-240
- https://doi.org/10.1242/dev.126.2.229
Abstract
Mesoderm induction and patterning are mediated by members of the TGFbeta superfamily. We have isolated a novel zebrafish member, antivin, that structurally is highly related to mouse lefty. Overexpression of antivin completely abolishes mesoderm induction at blastula stage, yet resultant embryos develop well-patterned epidermal and neural derivatives. The mesoderm-inhibiting activity of antivin can be mimicked by lefty and is suppressed by increasing levels of the mesodermal inducer Activin or its receptors. On the basis of its expression and activity, we propose that Antivin normally functions as a competitive inhibitor of Activin to limit mesoderm induction in the early embryo.Keywords
This publication has 33 references indexed in Scilit:
- Zebrafish Nodal-Related Genes Are Implicated in Axial Patterning and Establishing Left–Right AsymmetryDevelopmental Biology, 1998
- Detection of ebaf, a novel human gene of the transforming growth factor beta superfamily association of gene expression with endometrial bleeding.Journal of Clinical Investigation, 1997
- one‐eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tubeGenes and Function, 1997
- Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryosNature, 1996
- Widespread expression of the eve1 gene in zebrafish embryos affects the anterior‐posterior axis patternDevelopmental Genetics, 1995
- Characterization of Mutated Transforming Growth Factor-.beta.s Which Possess Unique Biological PropertiesBiochemistry, 1994
- Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesodermCell, 1992
- Crystal Structure of Transforming Growth Factor-β2: an Unusual Fold for the SuperfamilyScience, 1992
- Mammalian subtilisins: The long-sought dibasic processing endoproteasesCell, 1991
- Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structuresCell, 1990