Useful Syntheses of (3S)-2,3,4,5-Tetrahydropyridazine-3-carboxylic Acid and Its Dehydrotetrapeptide Derivatives
- 1 November 1991
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 20 (11) , 1953-1956
- https://doi.org/10.1246/cl.1991.1953
Abstract
The stereoselective synthesis of (3S)-2,3,4,5-tetrahydropyridazine-3-carboxylic acid (Pya), which is a cyclic α-amino acid at center of antrimycins (1), was successful. Moreover, the synthesis of the C-terminal dehydrotetrapeptide of 1 containing Pya residue at N-terminus is described.This publication has 2 references indexed in Scilit:
- Asymmetric glycine enolate aldol reactions: synthesis of cyclosporin's unusual amino acid, MeBmtJournal of the American Chemical Society, 1986
- Antrimycin, a new peptide antibiotic.The Journal of Antibiotics, 1981