EFFECTS OF GLYCOPYRROLATE AND CIMETIDINE ON GASTRIC VOLUME AND ACIDITY IN PATIENTS AWAITING SURGERY
Open Access
- 1 December 1978
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 50 (12) , 1247-1250
- https://doi.org/10.1093/bja/50.12.1247
Abstract
Glycopyrrolate or cimetidine was administered before operation to patients undergoing elective surgery. After the induction of anaesthesia, the stomach contents were retrieved and the volume and pH measured. Neither drug diminished the volume of gastric contents compared with control. Glycopyrrolate produced little diminution in hydrogen ion concentration. Cimetidine caused a marked increase in pH with a mean [H+] 3.2 × 10−3 g litre1 compared with 1.4 × 102 g litre1 in the controls and 1.1 × 102 g litre1 in the glycopyrrolate group. Seventy-seven per cent of the patients receiving cimetidine had a pH greater than 2.5.This publication has 3 references indexed in Scilit:
- Effect of Low-Dose Propantheline on Food-Stimulated Gastric Acid SecretionNew England Journal of Medicine, 1977
- PULMONARY ACID ASPIRATION SYNDROME: SHOULD PROPHYLAXIS BE ROUTINE?British Journal of Anaesthesia, 1977
- ASPIRATION OF GASTRIC CONTENTS - AN EXPERIMENTAL STUDY1952