STUDIES OF THE INHIBITORY EFFECT OFl-TRIIODOTHYRONINE ON THYROIDAL I131UPTAKE IN EUTHYROID PERSONS AND PATIENTS WITH EXOPHTHALMIC GOITER*†
- 1 November 1956
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 16 (11) , 1480-1486
- https://doi.org/10.1210/jcem-16-11-1480
Abstract
In daily doses of 3.5 to 17.5 ug 1-triiodothyronine given to euthyroid subjects produced moderate though often transient inhibition of 24-hour uptake of I131 in most individuals. In daily doses of 25 to 140 [mu]g it uniformly produced prompt inhibition of 24-hour uptake, the larger the dose, the more rapid the inhibition. The intramuscular injection of 5 units of thyrotropin returned to normal or above-normal levels the 24-hour uptake of I131 previously decreased by ingestion of 1-triiodothyronine. There was no significant inhibition of 24-hour collection of I131 in 7 patients with exophthalmic goiter to whom 1-triiodothyronine was given.Keywords
This publication has 1 reference indexed in Scilit:
- Effect of Oral Thyroxine and Tri-Iodo-Thyronine on Radioactive Iodine Uptake and Serum Protein Bound Iodine in Normal Human SubjectsExperimental Biology and Medicine, 1953