Molecular conformation of thyrotropin-releasing hormone from the X-ray structural analysis of its tartrate

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Abstract
An X-ray crystal study of thyrotropin-releasing hormone tartrate has revealed that its molecular structure, in contrast with predictions based on energy calculations and n.m.r. spectroscopic studies, contains an extended peptide bond stabilized by a hydrogen bond between the π-NH unit of histidine and the carbonyl oxygen of the proline amide.