Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium
Open Access
- 1 May 1995
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 115 (2) , 222-224
- https://doi.org/10.1111/j.1476-5381.1995.tb15866.x
Abstract
Rabbit hearts were preconditioned with four 5 min coronary artery occlusions 24 h before 30 min coronary occlusion with 120 min reperfusion. Preconditioning significantly reduced the percentage of myocardium infarcting within the risk zone from 49.1 ±4.3% to 31.8±3.5% (P<0.05). When the protein kinase C (PKC) inhibitor, chelerythrine, was administered just before preconditioning, the delayed protection against infarction 24 h later was abolished. We conclude that the delayed cytoprotective response associated with ischaemic preconditioning of myocardium is likely to involve the early activation of one or more PKC subtypes.Keywords
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