Unsaturated α-aminopimelic acids as potent inhibitors of meso-diaminopimelic acid (DAP) D-dehydrogenase
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 6,p. 555-556
- https://doi.org/10.1039/a900297i
Abstract
Two nonproteinogenic amino acids 5 and 6 have been efficiently prepared using an SH2′ allylstannane coupling reaction and a Wittig reaction, respectively, to effect the key steps; kinetic studies show these compounds to be reversible inhibitors of DAP dehydrogenase with Ki values of 5.3 (competitive) and 44 µM (noncompetitive), respectively.Keywords
This publication has 0 references indexed in Scilit: