Ki-67 Antibody Labeling Index in Colorectal Carcinoma
- 1 December 1992
- journal article
- Published by Wolters Kluwer Health in Journal of Clinical Gastroenterology
- Vol. 15 (4) , 317-320
- https://doi.org/10.1097/00004836-199212000-00010
Abstract
Ki-67 labeling index of 58 colorectal carcinomas and 10 normal colonic mucosa samples was determined by the use of an immunohistochemical staining technique. The Ki-67 labeling index in colorectal carcinomas ranged from 15.7 to 63.6% (mean +/- SD of 38.5 +/- 10.5) and was significantly higher than the index for normal colon mucosa (mean +/- SD of 14.1 +/- 2.8). The mean Ki-67 labeling index was significantly higher in Dukes' B and Dukes' C tumors than in Dukes' A tumors, but the index did not correlate with the size of the tumor. There was no correlation between the Ki-67 labeling index of the tumor and lymph node involvement. The present study disclosed that the Ki-67 labeling index correlated with local invasion of colorectal carcinoma, but not with metastasis of the tumor.Keywords
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