DIFFERENTIAL REACTIVITY OF MICE TO ALLOANTIGENS ASSOCIATED WITH THE D AND K END OF H-2

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Abstract
SUMMARY Allograft reactions directed against antigens of the D and K end of the H-2b and H-2a alleles were compared in four congenic resistant strains of mice sharing the C57BL/10 background. Bone marrow cells of BIO and BIO.A donors were transplanted into irradiated recipients, and lymphoma cells of the same origin, into nonirradiated hosts. Allograft reactions against marrow cells were strong in D and D + K end incompatible mice, but were not detectable in K end incompatible hosts. The strength of antilymphoma reactions was either indistinguishable or considerably greater in K than in D end incompatible mice. By 10-fold serial dilutions of lymphoma cells, it was observed that the incidence of tumor takes increased paradoxically for the smaller inocula. This “dilution escape” from host surveillance occurred in K and K + D, but not in D end, incompatible mice. Thus, alloantigens of the two major H-2 subregions elicited different reactions in the congenic host mice used, which presumably shared regulator genes of allograft reactivity. Moreover, the opposite patterns observed in irradiated mice challenged with marrow, and in nonirradiated mice challenged with lymphoma grafts, strengthened the evidence for two distinct mechanisms of graft rejection in mice.

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