Effects of retinal and pineal low molecular weight fractions and antipsychotic drugs on hydroxyindole-O-methyltransferase
- 1 March 1983
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 58 (1-2) , 107-119
- https://doi.org/10.1007/bf01249129
Abstract
Fractions from bovine retinas and sheep pineals of low molecular weight decrease the activity of purified hydroxyindole-O-methyltransferase (HIOMT). The antipsychotic drugs chlorpromazine and haloperidol show a similar effect under the same experimental conditions. It is suggested that they may imitate the effect of (an) unknown natural suppressor(s) of HIOMT-activity, present in retina and pineal, decreasing the biosynthesis of methoxyindoles.This publication has 15 references indexed in Scilit:
- Inhibition of avian and mammalian hydroxy-indole-o-methyl-transferase (HIOMT) with low molecular weight fractions of mammalian pineal glandsLife Sciences, 1982
- HUMAN POST‐MORTEM PINEAL ENZYME ACTIVITYClinical Endocrinology, 1981
- Pteridines as nonretinal regulators of light-dependent melatonin biosynthesis.Proceedings of the National Academy of Sciences, 1980
- Separation of pineal extracts by gelfiltrationJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1977
- Separation of pineal extracts by gelfiltrationJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1976
- Separation of pineal extracts by gelfiltrationJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1975
- Drugs, Neurotransmitters, and SchizophreniaScience, 1974
- Localization of a sheep pineal antigonadotropinAnalytical Biochemistry, 1973
- Melatonin Synthesis in the Pineal Gland: Control by LightScience, 1963
- ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES1Journal of the American Chemical Society, 1958