Strong induction of activin expression after hippocampal lesion

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Abstract
WE studied the temporal and spatial mRNA expression pattern of activin/inhibin βA, βB and α subunits after unilateral kainic acid lesions of the hippocampal CA3 region. We found a strikingly increased expression of βA mRNA in the ipsilateral hippocampus 6–24 h after injury. By contrast, the βB and a mRNAs were expressed at equally low levels in normal and injured hippocampi, suggesting that the βA transcripts give rise to activin A, but not to activin AB or inhibin. In situ hybridization demonstrated the presence of βA mRNA in neurones near the site of lesion. Expression of all known types of activin receptors could be demonstrated in normal and injured hippocampi by RT-PCR. These findings suggest a role of activin in brain injury.

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