Dissociation of Homograft Response to Allogeneic versus Xenogeneic Skin Grafts in Irradiated Mice

Abstract
Lethally x-irradiated (C3H × DBA/2)F 1 mice were protected with syngeneic (isogenic) bone marrow and/ or prior treatment with urethan and skin grafted at various times after irradiation. The ability to reject a first-set xenogeneic (heterologous) skin graft with normal vigor returned within 92 days; the first-set response to allogeneic (homologous) grafts was still impaired 350 days after irradiation.

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