Nalidixic Acid-Induced Protein Alterations in Escherichia coli
Open Access
- 1 January 1977
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 11 (1) , 167-170
- https://doi.org/10.1128/aac.11.1.167
Abstract
The effect of nalidixic acid on pulse-labeled protein patterns was analyzed by sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis. The drug was found to alter protein patterns in a drug-sensitive strain but not in the isogenic drug-resistant strain of Escherichia coli. The drug-induced alteration of protein patterns was demonstrated by the appearance of some and the disappearance of other pulse-labeled peptides elicited by the drug.Keywords
This publication has 16 references indexed in Scilit:
- Nalidixic acid and bacterial chromosome replicationNature, 1976
- Enhancement by Nalidixic Acid of the Thermal Susceptibility of the Ts-7 Mutant of Escherichia Coli TAU-BarAntimicrobial Agents and Chemotherapy, 1975
- Nalidixic Acid: an Antibacterial ParadoxAntimicrobial Agents and Chemotherapy, 1975
- The effect of nalidixic acid on the expression of some genes in Escherichia coli K-12Biochemical and Biophysical Research Communications, 1975
- Selective inhibition of semiconservative DNA synthesis by nalidixic acid in permeabilized bacteriaBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974
- Studies on the Mechanism of Action of Nalidixic AcidAntimicrobial Agents and Chemotherapy, 1973
- Studies on the Mode of Action of Nalidixic AcidEuropean Journal of Biochemistry, 1972
- Sequential biosynthesis of the β and β′ subunits of the DNA-dependent RNA polymerase from Escherichia coliJournal of Molecular Biology, 1971
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970
- Biochemical Effects of Nalidixic Acid on Escherichia coliChemotherapy, 1965