Buspirone induced prolactin responses in obsessive—compulsive disorder (OCD)
- 1 January 1992
- journal article
- Published by Wolters Kluwer Health in International Clinical Psychopharmacology
- Vol. 7 (1) , 45-50
- https://doi.org/10.1097/00004850-199200710-00006
Abstract
Buspirone (BUSP) is a serotonergic (5-HT) agonist with activity at the 5-HT1A receptor. The BUSP induced prolactin (PRL) response was examined in 10 patients with a DSM IIIR diagnosis of obsessive-compulsive disorder (OCD). The results were compared with PRL responses to BUSP found in 10 age and sex matched healthy controls. The results suggest that the 5-HT1A receptor dysfunction may not be involved in the pathophysiology of OCD. The authors review the literature and consider the hypothesis that in OCD a complex interaction of other 5-HT receptor sub-types may be occurring, possibly with dysfunction primarily of the 5-HT2 receptors.Keywords
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