Selection of Ribosomal Mutants by Antibiotic Suppression in Yeast
- 24 December 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 174 (4016) , 1339-1341
- https://doi.org/10.1126/science.174.4016.1339
Abstract
Wild-type Saccharomyces cerevisiae is highly resistant to streptomycin. A histidine auxotroph was found which could grow without histidine in the presence of high concentrations of streptomycin. Selection for derivatives of this strain which could be suppressed by much lower concentrations of streptomycin yielded streptomycin-sensitive mutants which are cold-sensitive and have altered ribosomal profiles.Keywords
This publication has 18 references indexed in Scilit:
- ESCHERICHIA COLI RIBOSOMES: RECENT DEVELOPMENTSAnnual Review of Microbiology, 1969
- The Contrasting Role of strA and ram Gene Products in Ribosomal FunctioningPublished by Cold Spring Harbor Laboratory ,1969
- Ribosomes from Escherichia coli merodiploids heterozygous for resistance to streptomycin and to spectinomycinJournal of Molecular Biology, 1968
- Inhibition of mitochondrial synthesis in yeast by erythromycin: cytoplasmic and nuclear factors controlling resistanceGenetics Research, 1968
- THE BIOGENESIS OF MITOCHONDRIA IN SACCHAROMYCES CEREVISIAE The Journal of cell biology, 1967
- Modified ribosomes conferring resistance to cycloheximide in mutants of Saccharomyces cerevisiaeJournal of Molecular Biology, 1967
- Classification of aminotransferase (C gene) mutants in the histidine operonJournal of Molecular Biology, 1966
- An Enrichment Method for Auxotrophic Yeast Mutants using the Antibiotic ‘Nystatin’Nature, 1966
- Ribosomal AmbiguityCold Spring Harbor Symposia on Quantitative Biology, 1966
- Suppression activated by streptomycin and related antibiotics in drug sensitive strainsBiochemical and Biophysical Research Communications, 1965