Variation in complement factor 3 is associated with risk of age-related macular degeneration
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- 2 September 2007
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 39 (10) , 1200-1201
- https://doi.org/10.1038/ng2131
Abstract
The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample.Keywords
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