Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro
Open Access
- 1 March 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 37 (3) , 617-622
- https://doi.org/10.1093/jac/37.3.617
Abstract
The efficacy of combination therapy with 5-flucytosine and an IgGl monocional antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774.16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgGl was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.Keywords
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