PREVENTION OF ABORTION AND NEONATAL DEATH DUE TO TOXOPLASMOSIS BY VACCINATION OF GOATS WITH THE NON-PATHOGENIC COCCIDIUM HAMMONDIA-HAMMONDI

  • 1 January 1981
    • journal article
    • research article
    • Vol. 42  (12) , 2155-2157
Abstract
Six does serologically negative to Toxoplasma gondii were vaccinated with 1 x 106 oocysts of the nonpathogenic coccidium H. hammondi 17-73 days before breeding. Two does were not inoculated with H. hammondi. All does were mated with a T. gondii-free buck. Between the 51st-119th days of their pregnancies, 5 of 6 Hammondia-vaccinated doses and the 2 controls were each inoculated orally with 1000 infective oocysts of the GT-1 strain of T. gondii. Of the 5 Toxoplasma-inoculated vaccinated does 4 gave birth to 8 apparently healthy kids at the expected gestation period. The 5th vaccinated doe gave birth to 3 kids that died during delivery or were born dead. T. gondii was isolated in mice inoculated with tissues of all kids born to vaccinated does. The vaccinated doe which was not inoculated with T. gondii gave birth to 2 healthy noninfected kids. Of the 2 control pregnant does (not vaccinated, but inoculated with T. gondii), 1 aborted due to toxoplasmosis 17 days after inoculation. The other control doe had 2 dead fetuses and retained fetal membranes in uterus when necropsied at the expected parturition time. It might be possible to develop a vaccine against toxoplasmic abortions in animals.

This publication has 2 references indexed in Scilit: