Dissociation Constants of Ethane-1-hydroxy-1,1-diphosphonate [EHDP] and Dichloromethylene-diphosphonate [Cl2MDP] for H+, Ca2+, Mg2+ and Zn2+
Open Access
- 1 December 1976
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C
- Vol. 31 (11-12) , 661-663
- https://doi.org/10.1515/znc-1976-11-1206
Abstract
The diphosphonates EHDP and Cl2MDP have been used for studying bone metabolism and for treatment of bone diseases. The Kd of EHDP and Cl2MDP for H+, Ca2+, Mg2+ and Zn2+ were determined from pH titration curves. EHDP forms more stable chelates with Ca2+, Mg2+ and Zn2+ than Cl2MDP. CL2MDP is a stronger acid than EHDP.Keywords
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