Concentration of norfloxacin in human gallbladder tissue and bile after single-dose oral administration
Open Access
- 1 February 1987
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 31 (2) , 352-353
- https://doi.org/10.1128/aac.31.2.352
Abstract
Concomitant concentrations of norfloxacin in serum and in gallbladder tissue and bile were determined in 10 patients after a single oral dose of 400 mg given before cholecystectomy. Concentrations in gallbladder bile ranged from 0.6 to 15.6 micrograms/ml, with a mean bile/serum ratio of 7.0. The mean concentration in gallbladder tissue was 1.8 +/- 0.8 (standard error) micrograms/g.This publication has 4 references indexed in Scilit:
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- The fluoroquinolones: pharmacology, clinical uses, and toxicities in humansAntimicrobial Agents and Chemotherapy, 1985
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- In vitro antibacterial activity of norfloxacin compared with eight other antimicrobial agentsEuropean Journal of Clinical Microbiology & Infectious Diseases, 1983