Intrapulmonary Penetration of Voriconazole in Patients Receiving an Oral Prophylactic Regimen
Open Access
- 1 May 2006
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (5) , 1878-1880
- https://doi.org/10.1128/aac.50.5.1878-1880.2006
Abstract
Voriconazole penetrated well into the pulmonary epithelial lining fluid (ELF) in lung transplant patients receiving oral prophylaxis. The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (±8). A strong association between plasma and ELF concentrations (r2 = 0.95) was noted.Keywords
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