THE INFLUENCE OF AN ANGIOTENSIN II ANTAGONIST, SARALASIN, GIVEN BEFORE DONOR NEPHRECTOMY, ON KIDNEY FUNCTION AFTER TRANSPLANTATION

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Abstract
Kidneys from [human] cadaver donors who were treated during the last 10 min before bilateral nephrectomy with an infusion of 10 .mu.g/kg-1 per min-1 (Sar1,Val5,Ala8)-angiotensin II [saralasin] had a remarkable, significantly lower percentage of acute renal failure (25%) after renal transplantation than untreated kidneys (58.3%). Anuria was seen in the treated group only in 4.2%, although it occurred in the untreated control group in 16.6%. The role of the activated renin-angiotensin system in postischemic acute renal failure is discussed.