An Expeditious Synthesis of Dimethyl 1-Benzyl-cis-Piperidine-3,5-Dicarboxylate
- 1 January 1997
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 27 (1) , 69-77
- https://doi.org/10.1080/00397919708004806
Abstract
A mixture of dimethyl 1-benzyl-cis-and trans-piperidine-3,5-dicarboxylate is prepared in high yields from readily available starting materials, by a reliable procedure. The straightforward conversion of the mixture into the diastereomerically pure cis-isomer, a useful [sgrave]-symmetry intermediate for alkaloid synthesis, is also described.Keywords
This publication has 3 references indexed in Scilit:
- Stereoselective enzymatic hydrolysis of dimethyl meso-piperidine-3,5-dicarboxylatesTetrahedron: Asymmetry, 1996
- First Enantioselective Synthesis of (-)-Akagerine by a Chemoenzymic ApproachThe Journal of Organic Chemistry, 1995
- über Verbindungen mit Urotropin‐Struktur, VI. Mitteil.: Synthese des 1.3‐Diaza‐adamantansEuropean Journal of Inorganic Chemistry, 1955