Organoiron complexes in organic synthesis. Part 23. New strategies for steroid and aphidicolane synthesis
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 11,p. 2631-2639
- https://doi.org/10.1039/p19820002631
Abstract
Methodologyallowing the application of tricarbonyl(4-methoxy-1 -methylcyclohexadienylium)iron hexafluorophosphate(1a) as a ring A synthon for the construction of D-homoaromatic steroid derivatives is described, via its regiospecific reaction with the potassium enolate of methyl 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate. A model study is presented towards the conversion of (1a) into the tetracyclic diterpene aphidicolin (12), in which the complex is converted in 12 steps to the spirotricyclic compound (46).This publication has 6 references indexed in Scilit:
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