THE EFFECT OF RATTLESNAKE VENOM (CROTALIN) ON THE PLASMA HISTAMINE OF THE RABBIT

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Abstract
Normal rabbits were injected intraven. with a 50% aq. soln. of glycerol containing 1 mg. of dried rattlesnake venom (Crotalus horridus). There was a definite decrease in the conc. of plasma histamine after the first inj. of venom. The rabbit possesses a mechanism for the relatively speedy removal of histamine from the blood, and probably in this type of shock, and probably in anaphylactic shock also, histamine may be released, as in animals of other spp., but because of the efficiency of this removal mechanism of the rabbit even the normally circulating histamine largely disappears.

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