PENICILLIN TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS
- 6 November 1948
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 138 (10) , 726-730
- https://doi.org/10.1001/jama.1948.02900100006002
Abstract
Prior to the use of chemotherapeutic agents, subacute bacterial endocarditis was rarely if ever cured. With the increasing use of sulfonamide compounds in the treatment of this condition, series of cases were reported in which apparent cures were achieved in approximately 5 per cent of patients treated.1Recent experience with penicillin in a number of well substantiated series2indicates that the percentage of patients cured is substantially higher than among patients treated with sulfonamide compounds. It is the purpose of this communication to show the results of penicillin therapy in 18 consecutive cases of subacute bacterial endocarditis. CLINICAL DATA Selection of Cases.— In the two year period from Jan. 1, 1944 to Dec. 31, 1945, 18 patients with subacute bacterial endocarditis were admitted to St. Luke's Hospital. The diagnosis was established in each instance by the clinical history, physical findings and repeated positive blood cultures. Table 1 showsKeywords
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